03 AUG 16:45
Scientists discover new potential drugs against COVID-19
Scientists have discovered potential drug targets for various diseases, including cancer, rheumatoid arthritis and COVID-19, an article published in the journal Molecular Cell reported.
When viruses or bacteria enter the human body, the complement system, a complex of protective proteins constantly present in the blood, is activated, including two different membrane receptors called C5aR1 and C5aR2. This mechanism is necessary to fight harmful pathogens, however, excessive and prolonged activation leads to the development of inflammation and even life-threatening conditions, such as, for example, with complications of COVID-19.
Scientists have uncovered the internals of C5aR2 using CRISPR and cryogenic electron microscopy, which has provided an additional opportunity for therapeutic effects on COVID-19.
For the treatment of COVID-19, some scientists are already trying to block the C5aR1 receptor. Clinical trials of avdoralimab are also underway in patients with severe pneumonia caused by SARS-CoV-2. According to scientists, the study opens up the possibility of influencing C5aR2 with new drug molecules that can bind to this receptor and block its activation.
Scientists have uncovered the internals of C5aR2 using CRISPR and cryogenic electron microscopy, which has provided an additional opportunity for therapeutic effects on COVID-19.
For the treatment of COVID-19, some scientists are already trying to block the C5aR1 receptor. Clinical trials of avdoralimab are also underway in patients with severe pneumonia caused by SARS-CoV-2. According to scientists, the study opens up the possibility of influencing C5aR2 with new drug molecules that can bind to this receptor and block its activation.
